… How GC infect the female reproductive tract (FRT) and cause … human cervical explants to
examine the mechanism by which GC infect the heterogeneous mucosa of the human cervix, …

… composed of a heterogeneous mixture of epithelia, forming a … performed with primary human
cervical epithelial cells indicate … This is evident from the different mechanisms used by this …

… cells using distinct mechanisms. (A) … , 5 we established human cervical tissue explants as
an infection model. In this system, the epithelia maintain their in vivo heterogeneous properties …

… gonorrhoeae and lead to differences in the mechanisms by … vaginal and cervical epithelial
cells infected with N. … may explain the heterogeneity of symptoms in infected individuals. Opa–…

… gonorrhoeae is an obligate human pathogen, and predominantly infects the mucosal
epithelium of the human … evasion mechanisms of the gonococcus in both cervical epithelial cells …

… lines lack the heterogeneity of the luminal epithelium. Additionally, … Ruffle formation in primary
cervical epithelial cells is mediated … This may account for asymptomatic cervical infections. …

… acute gonorrhoea in a woman (cervix). An infectious unit is partially inside the epithelial
cell. … 1, 2 and 10) and between the great variety of morphologically heterogeneous vesicular …

… Our laboratory and others have showed different mechanisms … and epithelial cells showed
different results (56–59). A study … in MDM infected cells compared to non-infected MDM cells, …

… different mechanisms of pathogenesis used by N. gonorrhoeae to infect, to invade, and to
colon ize the mucosal epithelia … gonorrhoeae-infected primary human cervical epithelial cells …

… between populations, with heterogeneity linked to multiple … epithelial cells and/or indirectly
by the disruption of epithelial … More recently, primary human cervical explants have been …